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| FEDER,DAVID; PERRAZO,FABIO F.; PEREIRA,EDIMAR C.; FORSAIT,SILVANA; FEDER,CECíLIA K.R.; JUNQUEIRA,PAULO E.B.; JUNQUEIRA,VIRGINIA B.C.; AZZALIS,LIGIA A.; FONSECA,FERNANDO L.A.. |
| In the adult organism, angiogenesis is restricted to a few physiological conditions. On the other hand, uncontrolled angiogenesis have often been associated to angiogenesis-dependent pathologies. A variety of animal models have been described to provide more quantitative analysis ofin vivo angiogenesis and to characterize pro- and antiangiogenic molecules. However, it is still necessary to establish a quantitative, reproducible and specific method for studies of angiogenesis factors and inhibitors. This work aimed to standardize a method for the study of angiogenesis and to investigate the effects of thalidomide on angiogenesis. Sponges of 0.5 x 0.5 x 0.5 cm were implanted in the back of mice groups, control and experimental (thalidomide 200 mg/K/day by... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Angiogenesis model; Hemoglobin measurement; Sponge implant; Thalidomide. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000401483 |
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