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| Ali,Tariq; Shoaib,Muhammad Harris; Yousuf,Rabia Ismail; Jabeen,Sabahat; Muhammad,Iyad Naeem; Tariq,Asfia. |
| The aim of the present study was to develop tizanidine controlled release matrix. Formulations were designed using central composite method with the help of design expert version 7.0 software. Avicel pH 101 in the range of 14-50% was used as a filler, while HPMC K4M and K100M in the range of 25-55%, Ethylcellulose 10 ST and 10FP in the range of 15 - 45% and Kollidon SR in the range of 25-60% were used as controlled release agents in designing different formulations. Various physical parameters including powder flow for blends and weight variation, thickness, hardness, friability, disintegration time and in-vitro release were tested for tablets. Assay of tablets were also performed as specified in USP 35 NF 32. Physical parameters of both powder blend and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tizanidine/controlled release; Hydroxypropyl methylcellulose/controlled release agent; Ethylcellulose/controlled release agent; Kollidon SR/controlled release agent; Tablets/controlled release. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400799 |
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| Israr,Fozia; Mahmood,Zafar Alam; Hassan,Fouzia; Hasan,Syed Muhammad Farid; Jabeen,Sabahat; Naz,Shazia; Bashir,Lubna. |
| Cefuroxime axetil immediate release tablets were formulated by direct compression method with different percentages of sodium lauryl sulphate (SLS) such as 0.5, 1.0, 1.5 and also without SLS. Resulting batches of tablets were evaluated by both pharmacopeial and non-pharmacopeial methods to ascertain the physico-mechanical properties. Dissolution test were carried out in different medium like 0.07 M HCl, distilled water, 0.1M HCl of pH 1.2 and phosphate buffers at pH 4.5 and 6.8 to observe the drug release against the respective concentration of SLS used. Later, test formulations were compared by f1(dissimilarity) and f2(similarity) factors using a reference brand of cefuroxime axetil. Significant differences (p<0.05) in dissolution rate were recorded... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Cefuroxime axetil/immediate release tablets/physico-mechanical properties; Direct compression; Sodium lauryl sulphate. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400943 |
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