|
|
|
|
|
| Alandijany, T.; Kammouni, W.; Roy Chowdhury, S. K.; Fernyhough, P.; Jackson, A. C.. |
| Neuronal process degeneration occurs in an experimental mouse model of rabies with hindlimb footpad inoculation of the challenge virus standard-11 (CVS) strain. CVS infection of primary mouse and rat dorsal root ganglion (DRG) neurons has associated axonal degeneration with axonal swellings and neurite outgrowth reduction. The CVSinduced axonal swellings feature protein adducts of 4-hydroxy-2-nonenal (4-HNE), a marker for lipid peroxidation, indicating a critical role of oxidative stress. Western immunoblotting analysis indicated that adducts of 4-HNE expression is also increased in the CVS-infected rat adrenal medulla (PC12) cell line. Mitochondrial dysfunction is one of the most important causes for overproduction and accumulation of reactive oxygen... |
| Tipo: Info:eu-repo/semantics/article |
|
| Ano: 2013 |
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/241 |
| |
|
|
| Udow, S. J.; Marrie, R. A.; Jackson, A. C.. |
| Clinical differences in rabies due to canine and bat rabies virus variants have been noted, but no detailed studies have been reported to support these observations. Using PubMed and the MMWR we identified 120 case reports of rabies from the USA, Canada, Europe, and Asia. We systematically abstracted selected clinical features, results of investigations, incubation times and durations of illness. Details about clinical features were recorded. Cases were classified as dog- or bat-acquired based on reported animal exposure or viral variant typing by molecular or monoclonal antibody characterization. Categorical variables were summarized as frequency (%), and continuous variables were summarized as median (interquartile range [IQR]). We compared batand... |
| Tipo: Info:eu-repo/semantics/article |
|
| Ano: 2013 |
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/234 |
| |
|
|
|
