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	Provedor de dados BJPS (2) Autor Chabukswar,Aniruddha Rajaram (2) Jagdale,Swati Changdeo (2) Kuchekar,Bhanudas Shankar (2) Gawali,Vaibhav Uttam (1) Jadhav,Vinayak Narhari (1) Palavra-chave Cyclodextrin (1) Diltiazem hydrochloride (1) Drugs/taste-masking (1) Fast-dissolving tablets (1) Freeze-drying (1) Nifedipine/dissolution (1) Superdisintegrants (1) Β-ciclodextrin/complexation (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2012 (1) 2011 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Formulation and in vitro evaluation of taste-masked oro-dispersible dosage form of diltiazem hydrochloride BJPS Jagdale,Swati Changdeo; Gawali,Vaibhav Uttam; Kuchekar,Bhanudas Shankar; Chabukswar,Aniruddha Rajaram. Diltiazem hydrochloride is a calcium channel blocker generally indicated for the treatment of angina and hypertension, and it is extensively metabolized due to the hepatic metabolism. Formulation of diltiazem hydrochloride into an oro-dispersible dosage form can provide fast relief with higher bioavailability. The bitter taste of the drug should be masked to formulate it in a palatable form. In the present work, an attempt was made to mask the taste by complexation technique, with a formulation into an oro-dispersible dosage form, using superdisintegrants Doshion P544, crospovidone (CP) and sodium starch glycolate (SSG). The complexes of diltiazem hydrochloride with β-CD (1:1 molar ratio) were prepared by kneading, co-evaporation, co-grounding,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Diltiazem hydrochloride; Cyclodextrin; Drugs/taste-masking; Freeze-drying. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000400028 Solubility enhancement, physicochemical characterization and formulation of fast-dissolving tablet of nifedipine-betacyclodextrin complexes BJPS Jagdale,Swati Changdeo; Jadhav,Vinayak Narhari; Chabukswar,Aniruddha Rajaram; Kuchekar,Bhanudas Shankar. The main objective of the study was to enhance the dissolution of nifedipine, a poorly water soluble drug by betacyclodextrin complexation and to study the effect of the preparation method on the in vitro dissolution profile. The stoichiometric ratio determined by phase solubility analysis for inclusion complexation of nifedipine with β-cyclodextrin was 1:1. Binary complex was prepared by different methods and was further characterized using XRD, DSC and FT-IR. A saturation solubility study was carried out to evaluate the increase in solubility of nifedipine. The optimized complex was formulated into fast-dissolving tablets by using the superdisintegrants Doshion P544, pregelatinized starch, crospovidone, sodium starch glycolate and croscarmellose sodium... Tipo: Info:eu-repo/semantics/article Palavras-chave: Fast-dissolving tablets; Nifedipine/dissolution; Β-ciclodextrin/complexation; Superdisintegrants. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100015 Registros recuperados: 2 Primeira ... 1 ... Última

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