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	Provedor de dados BJMBR (1) Autor Fang,M. (1) Jin,A. (1) Liu,X. (1) Zhao,Y. (1) Palavra-chave Acetylate (1) Apoptosis (1) Glyceraldehyde-3-phosphate dehydrogenase (1) Homocysteine (1) P300/CBP (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2016 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Homocysteine induces glyceraldehyde-3-phosphate dehydrogenase acetylation and apoptosis in the neuroblastoma cell line Neuro2a BJMBR Fang,M.; Jin,A.; Zhao,Y.; Liu,X.. High plasma levels of homocysteine (Hcy) promote the progression of neurodegenerative diseases. However, the mechanism by which Hcy mediates neurotoxicity has not been elucidated. We observed that upon incubation with Hcy, the viability of a neuroblastoma cell line Neuro2a declined in a dose-dependent manner, and apoptosis was induced within 48 h. The median effective concentration (EC50) of Hcy was approximately 5 mM. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) nuclear translocation and acylation has been implicated in the regulation of apoptosis. We found that nuclear translocation and acetylation of GAPDH increased in the presence of 5 mM Hcy and that higher levels of acetyltransferase p300/CBP were detected in Neuro2a cells. These findings... Tipo: Info:eu-repo/semantics/article Palavras-chave: Homocysteine; Glyceraldehyde-3-phosphate dehydrogenase; Apoptosis; Acetylate; P300/CBP. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000200606 Registros recuperados: 1 Primeira ... 1 ... Última

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