|
|
|
|
|
| Sun,J.; Jin,G.; Qin,M.X.; Wan,Z.B.; Wang,J.B.; Wang,C.; Guo,W.Y.; Xu,L.; Ning,X.; Xu,J.; Pu,X.J.; Chen,M.S.; Zhao,H.M.. |
| Acute cerebral hemorrhage (ACH) is an important clinical problem that is often monitored and studied with expensive devices such as computed tomography, magnetic resonance imaging, and positron emission tomography. These devices are not readily available in economically underdeveloped regions of the world, emergency departments, and emergency zones. We have developed a less expensive tool for non-contact monitoring of ACH. The system measures the magnetic induction phase shift (MIPS) between the electromagnetic signals on two coils. ACH was induced in 6 experimental rabbits and edema was induced in 4 control rabbits by stereotactic methods, and their intracranial pressure and heart rate were monitored for 1 h. Signals were continuously monitored for up to... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute cerebral hemorrhage; Magnetic induction phase shift; Electromagnetic properties of biological tissues; Intracranial pressure. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000200144 |
| |
|
|
| Zhu,M.Z.; Le,W.D.; Jin,G.. |
| Ropinirole (ROP) is a dopamine agonist that has been used as therapy for Parkinson's disease. In the present study, we aimed to detect whether gene expression was modulated by ROP in SH-SY5Y cells. SH-SY5Y cell lines were treated with 10 µM ROP for 2 h, after which total RNA was extracted for whole genome analysis. Gene expression profiling revealed that 113 genes were differentially expressed after ROP treatment compared with control cells. Further pathway analysis revealed modulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway, with prominent upregulation of PIK3C2B. Moreover, batches of regulated genes, including PIK3C2B, were found to be located on chromosome 1. These findings were validated by quantitative RT-PCR and Western blot... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Parkinson's disease; Gene expression; Ropinirole; SH-SY5Y. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000200607 |
| |
|
|
|
