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	Provedor de dados Nature Precedings (1) Autor Boris Cvek (1) Jan Taraba (1) Jitka Ulrichova (1) Lukas Muller (1) Radim Vrzal (1) Zdenek Dvorak (1) Mais... Palavra-chave Cancer (1) Chemistry (1) Molecular Cell Biology (1) Pharmacology (1) Tipo do documento Poster (1) Ano 2007 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Opposite effects of two zinc(II) dithiocarbamates on NF-kB pathway Nature Precedings Boris Cvek; Zdenek Dvorak; Jan Taraba; Lukas Muller; Radim Vrzal; Jitka Ulrichova. Inhibiting nuclear factor-kappaB (NF-kB) activation in anticancer and antiinflammatory therapy is of topical interest. Current research in molecular biology has dramatically advanced in the understanding of the cellular events involved in NF-kB induction. Dithiocarbamates, in particular diethyldithiocarbamate and pyrrolidinedithiocarbamate, have been known and widely used as strong inhibitors of NF-kB signaling pathway for more than ten years. Their activity is frequently thought to be due to chelating of zinc or copper present in serum supplemented in the culture medium. Zinc(II) diethyldithiocarbamate (Et2Zn) and zinc(II) dibenzyldithiocarbamate (Bz2Zn) were prepared by direct synthesis in aqueous millieu. They were structurally characterized by X-ray... Tipo: Poster Palavras-chave: Cancer; Chemistry; Molecular Cell Biology; Pharmacology. Ano: 2007 URL: http://precedings.nature.com/documents/735/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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