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	Provedor de dados Biocell (4) Autor Joubert,Annie (4) Marais,Sumari (2) Laurens,Johannes (1) Lottering,Mona-Liza (1) Maritz,Christine (1) Mqoco,Thandi (1) Van Zyl,Hermia (1) Vorster,Chris (1) Mais... Palavra-chave Apoptosis (3) 2-methoxyestradiol (2) Autophagy (2) Cancer (2) Breast cancer (1) Breast carcinoma (1) Estradiol metabolism (1) Mitosis (1) Sulphamoylated estradiol derivative (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Info:eu-repo/semantics/report (1) Ano 2010 (2) 2009 (2) País Argentina (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última C2- and C4-position 17β-estradiol metabolites and their relation to breast cancer Biocell Joubert,Annie; Van Zyl,Hermia; Laurens,Johannes; Lottering,Mona-Liza. C2- and C4-position 17β-estradiol metabolites play an important role in breast carcinogenesis. 2-Hydroxyestradiol and 4-hydroxyestradiol are implicated in tumorigenesis via two pathways. These pathways entail increased cell proliferation and the formation of reactive oxygen species that trigger an increase in the likelihood of deoxyribonucleic acid mutations. 2-Methoxyestradiol, a 17β-estradiol metabolite, however, causes induction of apoptosis in transformed and tumor cells; thus exhibiting an antiproliferative effect on tumor growth. The 4-hydroxyestradiol:2-methoxyestradiol and 2-hydroxyestradiol:2-methoxyestradiol ratios therefore ought to be taken into account as possible indicators of carcinogenesis. Tipo: Info:eu-repo/semantics/article Palavras-chave: Breast cancer; Estradiol metabolism; 2-methoxyestradiol. Ano: 2009 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452009000300001 In vitro effects of 2-methoxyestradiol-bis-sulphamate on cell growth, morphology and cell cycle dynamics in the MCF-7 breast adenocarcinoma cell line Biocell Vorster,Chris; Joubert,Annie. In the search for new and improved anticancer therapies, researchers have identified several potentially useful compounds. One of these agents is 2-methoxyestradiol-bis-sulphamate (2ME-BM), a sulphamoylated derivative of 2-methoxyestradiol. The objective of this study was to evaluate 2ME-BM's in vitro efficacy as antiproliferative agent in the MCF-7 breast adenocarcinoma cell line. Light- and fluorescent microscopy showed decreased cell density, increased apoptotic characteristics and significant ultrastructural aberrations indicative of autophagic cell death after 24 hours of exposure at a concentration of 0.4µM. In addition, mitotic indices revealed that 2ME-BM induces a G2M block. The latter was confirmed by flow cytometric analyses where increased... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cancer; 2-methoxyestradiol; Sulphamoylated estradiol derivative; Apoptosis; Autophagy. Ano: 2010 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000200003 Influence of estradiol analogue on cell growth, morphology and death in esophageal carcinoma cells Biocell Mqoco,Thandi; Marais,Sumari; Joubert,Annie. 2-Methoxyestradiol-bis-sulphamate is a bis-sulphamoylated derivative of the naturally occurring 17-beta-estradiol metabolite namely 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate is regarded as a potential anticancer drug with increased antiproliferative activity when compared to 2-methoxyestradiol. The aim of this pilot in vitro study was to determine the influence of 2-methoxyestradiol-bis-sulphamate on cell growth, morphology and possible induction of certain types of cell death in the SNO esophageal carcinoma cell line. A dose-dependent study (0.2-1.0µM) was conducted with an exposure time of 24 hours. Data revealed that 2-methoxyestradiol-bis-sulphamate reduced cell numbers statistically significantly to 74% after exposure to 0.4µM of the drug.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cancer; Apoptosis; Autophagy. Ano: 2010 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000300003 Influence of 2-methoxyestradiol on MCF-7 cells: An improved differential interference contrasting technique and Bcl-2 and Bax protein expression levels Biocell Joubert,Annie; Marais,Sumari; Maritz,Christine. Proteins of the B-cell lymphoma 2 family are crucial for the regulation of apoptosis. B-cell lymphoma 2-associated X is a pro-apoptotic protein, while B-cell lymphoma 2 protein opposes apoptosis. The influence of 1 μM 2-methoxyestradiol was investigated on the expression levels of these two proteins in MCF-7 cells. 2-Methoxyestradiol exposure did not influence B-cell lymphoma 2 protein expression levels after 24 h of exposure. In contrast, B-cell lymphoma 2-associated X protein levels were significantly reduced. An improved differential interference contrasting technique revealed compromised cell density and the presence of a mitotic block in exposed cells. The study proposes that the influence of 2-methoxyestradiol on the expression of these... Tipo: Info:eu-repo/semantics/report Palavras-chave: Breast carcinoma; Mitosis; Apoptosis. Ano: 2009 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452009000100007 Registros recuperados: 4 Primeira ... 1 ... Última

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