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A population-based study of glutathione-S-transferase M1, T1 and P1 genotypes Nature Precedings
Monika Sivoňová; Iveta Waczulíková; Dušan Dobrota; Tatiana Matáková; Jozef Hatok; Peter Račay; Ján Kliment.
A retrospective study on healthy, unrelated subjects was conducted in order to estimate population glutathione-S-transferases (GST) genotype frequencies in Slovak population of men and compare our results with already published data (GSEC project)^1^. A further aim of the study was to evaluate frequencies of the _GST_ polymorphisms also in patients with prostate cancer in order to compare the evaluated proportions with those found in the control subjects. Analysis for the _GST_ gene polymorphisms was performed by PCR and PCR-RFLP. We found that the proportions are not significantly different from those estimated in a European multicentre study or from the results published by another group in Slovakia. We found significantly increased age-standardized...
Tipo: Manuscript Palavras-chave: Cancer; Genetics & Genomics.
Ano: 2008 URL: http://precedings.nature.com/documents/2559/version/1
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