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| Jurkiewicz,Aron; Caricati-Neto,Afonso; Jurkiewicz,Neide H.. |
| The term functionomics (Amin 2003, Neumann et al. 2004) refers to a postgenomic integrated Systems Biology (Attur et al. 2002) using a multidimensional approach for cells, tissues and organs. It considers current or future involvement among genomics, proteomics or metabolomics, including the main factors that cause biological responses and modulation under different conditions. Our objective in the present review is to summarize the contemporary understanding of functionomics of smooth muscle pharmacology, based on the results obtained on the pregenomic era during several years in our laboratory. The present approach is based on the knowledge of the dynamics of the receptor system, which comprises a cascade of phenomena, leading from the drug... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Functionomics; Receptor; Smooth muscle; Genomic. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300022 |
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| Ko,Gui Mi; Rosenkranz,Adela; Bertoncini,Clélia Rejane Antonio; Jurkiewicz,Neide Hyppolito; Franco,Mirian Ghiraldini; Jurkiewicz,Aron. |
| In this study, 602 samples were tested by the following assays performed at the animal facilities (Cedeme) of the Federal University of São Paulo (UNIFESP): 385 for dermal irritability, 90 for ocular irritability (discontinued in 1995), 31 for systemic toxicity by injection, 26 for oral acute toxicity, 15 for toxicity by intracutaneous injection, 15 for skin sensitization, 15 for toxicity of serum and vaccines for human use, 14 for toxicity by intramuscular implantation, 7 for pyrogens, 2 for acute dermal toxicity, and 2 for irritation of mucous membrane. The following agents were tested: cosmetics and related substances (42.0%), chemicals used in industry (32.9%), plastics, rubber, and other polymers (15.9%), agrotoxics (4.0%), medicines (2.7%), and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute biological assays/methods; Cosmetics/toxicity; Cosmetics/experimental study; Cosmetics/innocuity; Drugs/toxicity; Drugs/experimental study; Drugs/innocuity; Chemical substances/toxicity; Chemical substances/experimental study; Dermal irritability/experimental study. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000200012 |
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