Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BJPS (2) Autor Kadioglu,Yucel (2) Demirkaya-Miloglu,Fatma (1) Ozturk,Murat (1) Yaman,Mehmet Emrah (1) Palavra-chave Amlodipine/determination (1) Human plasma (1) Pharmaceutical formulations/quantitative analyis (1) Potassium losartan/central composite design (1) Spectrofluorimetric method/validation (1) Spectrofluorimetry/quantitative analysis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2014 (1) 2012 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Spectrofluorimetric determination of amlodipine in human plasma without derivatization BJPS Kadioglu,Yucel; Ozturk,Murat. A rapid and sensitive spectrofluorimetric method was developed for the determination of amlodipine (AD), a calcium channel blocker, in the plasma. The type of solvent, the wavelength range, and the range of AD concentration were selected to optimize the experimental conditions. The calibration curves were linear (r² >0.997) in the concentration range of 0.1-12.5 ppm of AD. The limit of quantitation and limit of detection values for the method for plasma samples were 0.1 ppm and 0.07 ppm, respectively. The precision calculated as the relative standard deviation was less than 3.5%, and the accuracy (relative error) was better than 5.5% (n=6). The method developed in this study can be directly and easily applied for the determination of AD in the plasma... Tipo: Info:eu-repo/semantics/article Palavras-chave: Amlodipine/determination; Spectrofluorimetric method/validation; Human plasma. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400016 Optimization of a spectrofluorimetric method based on a central composite design for the determination of potassium losartan in pharmaceutical products BJPS Demirkaya-Miloglu,Fatma; Yaman,Mehmet Emrah; Kadioglu,Yucel. Here, a spectrofluorimetric method for the determination of potassium losartan (PL) in pharmaceutical products is described. The effects of critical parameters, pH, acid molarity, and temperature, on the fluorescence intensity of PL were analyzed, and these parameters were optimized using a central composite design (CCD). The highest fluorescent intensity at excitation (λex) and emission (λem) wavelengths of 248 nm and 410 nm, respectively, was achieved using 0.01 M sulfurous acid (pH 2) at 21.6 °C. Under optimum conditions, the method was linear from 0.025-0.5 µg/mL, with a reasonably high correlation coefficient (0.9993). Furthermore, the method was very sensitive (LOQ, 0.006), accurate (RE, ≤7.06), and precise (%RSD, ≤6.51). After development and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Potassium losartan/central composite design; Spectrofluorimetry/quantitative analysis; Pharmaceutical formulations/quantitative analyis. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000300611 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco