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Effect of Lead Intoxication and D-Penicillamine Treatment on Hematological Indices in Rats International Journal of Morphology
Golalipour,Mohammad Jafar; Roshandel,Danial; Roshandel,Gholamreza; Ghafari,Soraya; Kalavi,Mergen; Kalavi,Khodaberdi.
Lead is one of the most important environmental pollution which is toxic to many organ systems. D-penicillamine (D-P) is a chelator drug which is used for treatment of lead toxicity for several years. This study was conducted in order to evaluate the efficacy of D-P in reducing the effects of lead on hematological indices. This study was done on 36 male adult, 6-8 weeks albino Wistar rats in Gorgan University of Medical Sciences. At first male adult rats were exposed to lead acetate in their drinking water. After 8 weeks, 6 rats were selected and blood samples were prepared to assess the effects of lead toxicity. The remained lead exposed rats were divided into recovery and treatment groups where distilled water and D-P was administered for them,...
Tipo: Journal article Palavras-chave: Lead toxicity; D-Penicillamine; Recovery; Blood indices; Rat.
Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400008
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