| The title may raise questions about definitions of the terms used. The more obvious ones are: 1) What is transfer? 2) How to define toxic; and 3) How to define feed or food. A more underlying question is how to measure the substances we are interested in. The (often) chemical methods used, are not always sensitive or specific enough. Sometimes, biologically based methods are used which detect a biological response, but seldom identify the compound responsible for that. Transfer is often not quantified in absolute terms but expressed in concentrations in feed and food. Mass balance between intake and excretion are quite rare as a steady state situation of residues in the animal is sometimes not obtained. Toxicity is mostly dependent on the concentration of... |
