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| Kelmer-Bracht,Ana M.; Fedatto-Júnior,Zélio; Ishii-Iwamoto,Emy L.; Caparroz-Assef,Silvana M.; Bracht,Adelar. |
| Ca2+ participates in the stimulation of hepatic gluconeogenesis by glucagon and there is evidence that Ca2+ fluxes are modified in arthritic rats. These findings raise the question whether hepatic gluconeogenesis in arthritic rats responds differently to glucagon and Ca2+. The experimental system was the isolated perfused rat liver. In the presence of Ca2+, stimulation of hepatic gluconeogenesis by glucagon in arthritic rats was equal to that in normal rats in absolute terms, but higher in relative terms (104.5 and 45.2%, respectively). In the absence of Ca2+, however, stimulation of hepatic gluconeogenesis by glucagon in arthritic rats was smaller in both absolute and relative terms (18.5 and 41.9%, respectively). It can be concluded that the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Arthritis; Liver; Gluconeogenesis; Glucagon. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000300009 |
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