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	Provedor de dados Nature Precedings (1) Autor Dang Vu-Phan (1) Kerby Shedden (1) Stephen Cooper (1) Palavra-chave Molecular Cell Biology (1) Tipo do documento Manuscript (1) Ano 2007 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Invariant mRNA content and mitotic protein breakdown as a solution to the Russian Doll problem of the mammalian cell cycle Nature Precedings Stephen Cooper; Kerby Shedden; Dang Vu-Phan. It is widely accepted that numerous genes are expressed in a cell-cycle dependent manner, with cycle-specific variations in mRNA content or peaks of protein content during the cell cycle. These proposed variations raise the problem of how varying cell cycle gene expression is regulated. This is the "infinite regression" problem or Russian Doll problem where postulating a cell-cycle specific control element merely pushes the explanation of cell-cycle variation back one step to the problem of how that control element itself appears and disappears at particular times during the cell cycle. We present evidence that cyclin mRNA content is invariant during the cell cycle and calculations reveal that mRNA variation does not account for observed... Tipo: Manuscript Palavras-chave: Molecular Cell Biology. Ano: 2007 URL: http://precedings.nature.com/documents/1218/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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