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| Rahim,Haroon; Sadiq,Abdul; Khan,Shahzeb; Chishti,Kamran Ahmad; Amin,Fazli; Khan,Mir Azam; Abbas,Sudhair. |
| ABSTRACT The aim of this study was to evaluate binding potential of Mulva neglecta mucilage (MNM) with subsequent comparison to PVP K30. Eight batches of Diclofenac sodium tablets were prepared by wet granulation technique keeping different concentrations (4, 6, 8 & 10% w/w) of Mulva neglecta mucilage (extracted from leaves of Mulva neglecta) and PVP K30 as standard binder. The granules of formulated batches showed bulk density (g/mL) 0.49 ± 0.00 to 0.57 ± 0.00, tapped density (g/mL) 0.59 ± 0.01 to 0.70 ± 0.01, Carr's index 09.27 ± 0.95 to 19.65 ± 0.59, Hausner's ratio 1.12 ± 0.00 to 1.24 ± 0.01 and angle of repose 30.37 ± 2.90 °C to 36.86 ± 0.94 °C. Tablets were compressed to hardness 7.50 to 7.95 kg/cm2. The tablets showed 0.39 ± 0.02 to 0.39 ± 0.01%... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Mulva neglecta/mucilage; Mulva neglecta/use as binder; Binders; Diclofenac sodium/tablets/drug release.. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000100022 |
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| Rahim,Haroon; Khan,Mir Azam; Badshah,Amin; Chishti,Kamran Ahmad; Khan,Salimullah; Junaid,Muhammad. |
| To evaluate binding potential of Prunus domestica gum in tablets formulations. Six tablet batches (F-1B to F-6B) were prepared by wet granulation method, containing Avicel pH 101 as diluent, sodium diclofenac as model drug using 10, 15 and 20 mg of Prunus domestica gum as binder and PVP K30 was used as standard binder. Magnesium stearate was used as lubricant. Flow properties of granules like bulk density, tapped density, Carr index, Hausner’s ratio, angle of repose as well as physical parameters of the compressed tablets including hardness, friability, thickness and disintegration time were determined and found to be satisfactory. The FTIR spectroscopic analysis showed that the formulation containing plant gum is compatible with the drug and other... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Prunus domestica/pharmaceutics; Plant gum/binder property; Plant binder; Tablets/formulations; Sodium diclofenac/tablets/analysis. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000100020 |
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