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	Provedor de dados Genet. Mol. Biol. (1) Autor Kalim,Muhammad (1) Khan,Muhammad Saleem Iqbal (1) Liang,Keying (1) Wang,Shenghao (1) Zhan,Jinbiao (1) Palavra-chave Antibody-drug conjugate (1) Biotherapeutics (1) Cancer therapy (1) Intracellular trafficking (1) PD-L1 (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2019 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Engineered scPDL1-DM1 drug conjugate with improved in vitro analysis to target PD-L1 positive cancer cells and intracellular trafficking studies in cancer therapy Genet. Mol. Biol. Kalim,Muhammad; Wang,Shenghao; Liang,Keying; Khan,Muhammad Saleem Iqbal; Zhan,Jinbiao. Abstract Antibody-drug conjugates (ADC), precisely deliver a cytotoxic agent to antigen-expressing tumor cells by using specific binding strategies of antibodies. The ADC has shown the ability of potent bio-therapeutics development but indefinite stoichiometric linkage and full-length antibody penetration compromised the field of its advancement. Single chain variable fragments convention instead of the full-length antibody may overcome the challenge of rapid penetration and internalization. Programmed cell death ligand-1 interaction with PD-1 has recently revolutionized the field of immunotherapy. We systematically designed scPDL1-DM1 drug conjugate by linking scFv-PD-L1 proteins (scFv) with maytansinoids (DM1) cytotoxic agent through succinimidyl... Tipo: Info:eu-repo/semantics/article Palavras-chave: Antibody-drug conjugate; Biotherapeutics; Cancer therapy; Intracellular trafficking; PD-L1. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000500101 Registros recuperados: 1 Primeira ... 1 ... Última

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