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	Provedor de dados 60 (1) Autor Chafle,Sandip Annaji (1) Khobragade,Deepak Shamrao (1) Lakhotia,Champalal Laxminarayan (1) Patil,Arun Trambak (1) Ujjainkar,Amol Prasadrao (1) Umathe,Sudhir Niranjanrao (1) Mais... Palavra-chave Diclofenac sodium/coating (1) Diclofenac sodium/pellets (1) Disintegration pH (1) Enteric coating/evaluation (1) Hot-melt coating/evaluation (1) Palmitic acid/coating (1) Palmitic acid/pellets (1) Pellets/coating (1) Pellets/evaluation (1) Stearic acid/coating (1) Stearic acid/pellets (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2012 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Development and evaluation of a hot-melt coating technique for enteric coating 60 Patil,Arun Trambak; Khobragade,Deepak Shamrao; Chafle,Sandip Annaji; Ujjainkar,Amol Prasadrao; Umathe,Sudhir Niranjanrao; Lakhotia,Champalal Laxminarayan. Conventional enteric coating requires the use of organic based polymers which are equally hazardous to the environment and operating personnel. Hot-melt coating avoids the use of solvents and is a safer and time-saving process. The present study was designed to assess the efficacy of hot-melt coating (HMC) as an enteric coating technique. Pellets prepared by extrusion spheronization were selected as the core formulation for a model of the gastric irritant drug diclofenac sodium (DFS) because of their innate advantages over single-unit formulations. Stearic acid (SA) and palmitic acid (PA) were evaluated as enteric hot-melt coating materials. HMC was carried out in a specially modified coating pan by applying SA and PA in molten state onto preheated pellets... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pellets/coating; Pellets/evaluation; Enteric coating/evaluation; Hot-melt coating/evaluation; Disintegration pH; Diclofenac sodium/pellets; Diclofenac sodium/coating; Palmitic acid/pellets; Palmitic acid/coating; Stearic acid/pellets; Stearic acid/coating. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100008 Registros recuperados: 1 Primeira ... 1 ... Última

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