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| Toyotome, Takahito; Fujiwara, Takayuki; Kida, Hideyuki; Matsumoto, Munehiro; Wada, Terumi; Komatsu, Ryoichi. |
| Azole antifungals are used not only clinically for fungal infections but also used as agricultural fungicides. Recently, azole-resistant Aspergillus fumigatus containing a tandem repeat in the promoter region of cyp51A combined with amino acid substitution(s) appears in the environment in Eurasia, especially in several European countries. Although azole fungicides have been used in Japan, especially in Hokkaido, surveillance and characterization of A. fumigatus in Hokkaido have not been reported. In this study, we collected soil samples from farms that used an azole fungicide in the Tokachi area of eastern Hokkaido, isolated 91 A. fumigatus strains, and determined the minimal inhibitory concentrations of medical azoles required for these strains. Moreover,... |
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Palavras-chave: Azole; Aspergillus fumigatus; Cyp51A. |
| Ano: 2016 |
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4469 |
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