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HLA-DRB1 alleles in juvenile-onset systemic lupus erythematosus: renal histologic class correlations BJMBR
Liphaus,B.L.; Kiss,M.H.B.; Goldberg,A.C..
Human leukocyte antigens (HLA) DRB1*03 and DRB1*02 have been associated with systemic lupus erythematosus (SLE) in Caucasians and black populations. It has been observed that certain HLA alleles show stronger associations with SLE autoantibodies and clinical subsets, although they have rarely been associated with lupus renal histologic class. In the present study, HLA-DRB1 allele correlations with clinical features, autoantibodies and renal histologic class were analyzed in a cohort of racially mixed Brazilian patients with juvenile-onset SLE. HLA-DRB1 typing was carried out by polymerase chain reaction amplification with sequence-specific primers using genomic DNA from 55 children and adolescents fulfilling at least four of the American College of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Systemic lupus erythematosus; Human leukocyte antigen; Lupus nephritis; Juvenile-onset lupus; HLA-DRB1 alleles.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000400019
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