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Glutathione S-transferase M1 (GSTM1) polymorphism in two Brazilian populations Genet. Mol. Biol.
Hatagima,Ana; Klautau-Guimarães,Maria Nazaré; Silva,Felizardo Penalva da; Cabello,Pedro Hernan.
The distribution of GSTM1 phenotype frequencies was studied in two Brazilian samples composed of healthy and unrelated blood donors of both sexes ranging in age from 18 to 61 years. The first sample consisted of 658 individuals from Rio de Janeiro, and the second included 179 individuals from Brasília. The GSTM1 phenotypes were detected using PCR reactions and subsequent digestion by the restriction enzyme HaeII. The GSTM1 null phenotype frequency was 46% and 49% for Rio de Janeiro and Brasília samples, respectively. The GSTM1 phenotype distributions were not in agreement with Hardy-Weinberg equilibrium in either sample, chi²1 = 11.49 (P < 0.001) for Rio de Janeiro and chi²1 = 6.77 (P < 0.01) for Brasília. This deviation from Hardy-Weinberg...
Tipo: Info:eu-repo/semantics/article
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572000000400003
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