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Congenital ventricular septal defects and prenatal exposure to cyclooxygenase inhibitors BJMBR
Burdan,F.; Szumilo,J.; Dudka,J.; Korobowicz,A.; Klepacz,R..
Ventricular septal defects (VSDs) are common congenital abnormalities which have been reported to be associated with maternal fever and various environmental factors. The aim of the present study was to evaluate the effect of prenatal exposure to cyclooxygenase (COX) inhibitors on heart defects. A retrospective statistical analysis was performed using data collected in our laboratory during various teratological studies carried out on albino CRL:(WI)WUBR Wistar strain rats from 1997 to 2004. The observations were compared with concurrent and historic control data, as well as findings from other developmental toxicological studies with selective and nonselective COX-2 inhibitors. Despite the lack of significant differences in the frequency of VSDs between...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cyclooxygenase; Cyclooxygenase inhibitor; Nonsteroidal anti-inflammatory drug; Ventricular septal defect.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000700011
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