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Immune restoration in human immunodeficiency virus and hepatitis C virus coinfected patients after highly active antiretroviral therapy BJID
Antonello,Vicente Sperb; Appel-da-Silva,Marcelo Campos; Kliemann,Dimas Alexandre; Santos,Breno Riegel; Tovo,Cristiane Valle.
OBJECTIVE: To evaluate the influence of hepatitis C virus on immunological and virological responses after highly active antiretroviral therapy initiation in human immunodeficiency virus/hepatitis C virus coinfected patients compared to monoinfected human immunodeficiency virus-infected patients. METHODS: The study enrolled 65 human immunodeficiency virus-1-infected subjects who initiated highly active antiretroviral therapy and attended follow-up visits over 48 weeks from 2008 to 2010. They were grouped based on hepatitis C virus-RNA results. Virological and immunological responses were monitored at baseline and at the end of weeks 12, 24, 36, and 48. RESULTS: There were 35 human immunodeficiency virus monoinfected and 30 human immunodeficiency...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HIV; Hepatitis C; Coinfection; HAART; CD4; Immunological response.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500007
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Identification of hepatitis B virus A1762T/G1764A double mutant strain in patients in Southern Brazil BJID
Silva Souza,Adaliany Cecília da; Souza Marasca,Giórgia de; Kretzmann-Filho,Nélson Alexandre; Dall-Bello,Aline; Kliemann,Dimas Alexandre; Tovo,Cristiane Valle; Veiga,Ana Beatriz Gorini da.
Abstract Infection by hepatitis B virus (HBV) is a worldwide public health problem. Chronic HBV infection with high viral replication may lead to cirrhosis and/or hepatocellular carcinoma. Mutant HBV strains, such as the HBV A1762T/G1764A double mutant, have been associated with poor prognosis and higher risk of the patient for developing cirrhosis and/or hepatocellular carcinoma. This study analyzed the presence of the HBV A1762T/G1764A double mutant in patients with chronic HBV and its association with clinical parameters such as viral load, aminotransferases, and HBV antigens. A total of 49 patients with chronic hepatitis B were included in the study, and the HBV A1762T/G1764A double mutant strain was detected in four samples (8.16%) by polymerase chain...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatitis B; HBV; A1762T/G1764A mutation.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500525
Registros recuperados: 2
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