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	Provedor de dados J. Venom. Anim. Toxins incl. Trop. Dis. (2) Autor Koohi,MK (2) Zare Mirakabadi,A (2) Boroumand,MA (1) Kassaaian,SE (1) Mahdavi,S (1) Purkabireh,M (1) Rabbani,SH (1) Sadeghian,S (1) Sotoudeh Anvari,M (1) Taghavian,M (1) Zayerzadeh,E (1) Mais... Palavra-chave Anticancer (1) Cytotoxic (1) Electrocardiogram changes (1) Histopathological changes (1) MDA-MB-231 (1) Mesobuthus eupeus (1) Necrosis (1) Scorpion experimental envenomation (1) Troponin (1) Venom peptides (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2010 (1) 2008 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Cytotoxic effect of ICD-85 (venom-derived peptides) on MDA-MB-231 cell line J. Venom. Anim. Toxins incl. Trop. Dis. Zare Mirakabadi,A; Mahdavi,S; Koohi,MK; Taghavian,M. Since 1987, when chemopreventive testing programs began, more than 1,000 agents and agent combinations have been selected and evaluated in preclinical studies of chemopreventive activity against various types of cancers. In the present study we aimed to provide quantitative and qualitative characterization of biological and pharmacological activities of ICD-85 on MDA-MB-231 cell line (a highly invasive breast cancer cell line) in order to gain a better understanding of the cytotoxic and apoptotic effects of this compound. For this study, the MDA-MB-231 cell line was used and the effect of ICD-85 was assayed by measuring the activity of the cytosolic enzyme lactate dehydrogenase (LDH), released into the culture medium after membrane damage. Morphological... Tipo: Info:eu-repo/semantics/article Palavras-chave: Venom peptides; MDA-MB-231; Anticancer; Necrosis; Cytotoxic. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000400005 Cardiopulmonary complications induced by Iranian Mesobuthus eupeus scorpion venom in anesthetized rabbits J. Venom. Anim. Toxins incl. Trop. Dis. Zayerzadeh,E; Koohi,MK; Zare Mirakabadi,A; Purkabireh,M; Kassaaian,SE; Rabbani,SH; Sotoudeh Anvari,M; Boroumand,MA; Sadeghian,S. Scorpion envenomation is a life-threatening condition, especially in children and elderly individuals affected by respiratory and cardiovascular diseases. In this study, the toxic effects of median lethal dose (LD50) injections of Mesobuthus eupeus (Me) venom on the heart and lungs of anesthetized rabbits were investigated. Six rabbits were selected and alterations in their electrocardiogram, heart rate, respiration and blood pressure before and after venom injection were recorded. Cardiac troponin T (cTnT), creatinine kinase muscle-brain fraction (CK-MB) and lactate dehydrogenase (LDH) were measured at 0, 1 and 3 hours after envenomation and pathology studies were carried out postmortem. All the animals showed signs and symptoms of envenomation within 40... Tipo: Info:eu-repo/semantics/article Palavras-chave: Mesobuthus eupeus; Scorpion experimental envenomation; Histopathological changes; Electrocardiogram changes; Troponin. Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000100006 Registros recuperados: 2 Primeira ... 1 ... Última

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