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| Pesic,V.; Radojevic,K.; Kosec,D.; Plecas-Solarovic,B.; Perisic,M.; Pilipovic,I.; Leposavic,G.. |
| The role of gonadal hormones in induction and, particularly, maintenance/progression of rat thymic involution, which normally starts around puberty, was reassessed by examining the effects of peripubertal orchidectomy on thymic weight and morphometric parameters at different times up to the age of 10 months. Up to 6 months post-castration both thymic weight and cellularity in orchidectomized (Cx) rats were greater than in age-matched control rats, sham Cx (Sx). The increase in thymic cellularity reflected an increase in thymocyte proliferation rate (the proportion of proliferating cells was 18.6 ± 0.7% in 2-month-old Cx (N = 5) vs 13.4 ± 0.3% (N = 5) in age-matched Sx rats) followed by reduced sensitivity to apoptotic signals (apoptotic thymocytes were 9.8... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Rat thymus; Aging; Orchidectomy; Stereological analysis; Thymocyte proliferation; Thymocyte apoptosis. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100009 |
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| Pilipović,I.; Kosec,D.; Radojević,K.; Perišić,M.; Pešić,V.; Stojić-Vukanić,Z.; Leposavi,G.. |
| There is evidence that the major mediators of stress, i.e., catecholamines and glucocorticoids, play an important role in modulating thymopoiesis and consequently immune responses. Furthermore, there are data suggesting that glucocorticoids influence catecholamine action. Therefore, to assess the putative relevance of glucocorticoid-catecholamine interplay in the modulation of thymopoiesis we analyzed thymocyte differentiation/maturation in non-adrenalectomized and andrenalectomized rats subjected to treatment with propranolol (0.4 mg·100 g body weight-1·day-1) for 4 days. The effects of β-adrenoceptor blockade on thymopoiesis in non-adrenalectomized rats differed not only quantitatively but also qualitatively from those in adrenalectomized rats. In... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Catecholamines; Glucocorticoids; Β-adrenoceptors; Propranolol; Thymocyte apoptosis; Thymocyte proliferation; Thymocyte differentiation. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000300009 |
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