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	Provedor de dados BJMBR (2) Autor Borges,D.R. (2) Kouyoumdjian,M. (2) Nagaoka,M.R. (2) de Araújo,L.J.T. (1) Palavra-chave AT1R (1) Adrenaline (1) Adrenoceptors (1) Angiotensin II (1) Inflammation (1) Kallikrein (1) Liver clearance (1) Liver perfusion (1) Thrombin (1) Tissue-type plasminogen activator (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2018 (1) 2000 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última The hepatic clearance of recombinant tissue-type plasminogen activator decreases after an inflammatory stimulus BJMBR Nagaoka,M.R.; Kouyoumdjian,M.; Borges,D.R.. We have shown that tissue-type plasminogen activator (tPA) and plasma kallikrein share a common pathway for liver clearance and that the hepatic clearance rate of plasma kallikrein increases during the acute-phase (AP) response. We now report the clearance of tPA from the circulation and by the isolated, exsanguinated and in situ perfused rat liver during the AP response (48-h ex-turpentine treatment). For the sake of comparison, the hepatic clearance of a tissue kallikrein and thrombin was also studied. We verified that, in vivo, the clearance of 125I-tPA from the circulation of turpentine-treated rats (2.2 ± 0.2 ml/min, N = 7) decreases significantly (P = 0.016) when compared to normal rats (3.2 ± 0.3 ml/min, N = 6). The AP response does not modify the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Liver clearance; Inflammation; Kallikrein; Thrombin; Tissue-type plasminogen activator. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100016 Participation of hepatic α/β-adrenoceptors and AT1 receptors in glucose release and portal hypertensive response induced by adrenaline or angiotensin II BJMBR de Araújo,L.J.T.; Nagaoka,M.R.; Borges,D.R.; Kouyoumdjian,M.. It has been previously demonstrated that the hemodynamic effect induced by angiotensin II (AII) in the liver was completely abolished by losartan while glucose release was partially affected by losartan. Angiotensin II type 1 (AT1) and adrenergic (∝1- and β-) receptors (AR) belong to the G-proteins superfamily, which signaling promote glycogen breakdown and glucose release. Interactive relationship between AR and AT1-R was shown after blockade of these receptors with specific antagonists. The isolated perfused rat liver was used to study hemodynamic and metabolic responses induced by AII and adrenaline (Adr) in the presence of AT1 (losartan) and ∝1-AR and β-AR antagonists (prazosin and propranolol). All antagonists diminished the hemodynamic response... Tipo: Info:eu-repo/semantics/article Palavras-chave: Liver perfusion; Angiotensin II; Adrenaline; AT1R; Adrenoceptors. Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200604 Registros recuperados: 2 Primeira ... 1 ... Última

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