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	Provedor de dados Nature Precedings (1) Autor Andrew L. Varnell (1) Donald C. Cooper (1) Eric M. Ostertag (1) Jun-Gang Wang (1) Kristin C. Rasmus (1) Palavra-chave Genetics & Genomics (1) Neuroscience (1) Tipo do documento Manuscript (1) Ano 2011 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Sociability is decreased following deletion of the _trpc4_ gene Nature Precedings Kristin C. Rasmus; Jun-Gang Wang; Andrew L. Varnell; Eric M. Ostertag; Donald C. Cooper. Shyness and social anxiety are predominant features of some psychiatric disorders including autism, schizophrenia, anxiety and depression. Understanding the cellular and molecular determinants of sociability may reveal therapeutic approaches to treat individuals with these disorders and improve their quality of life. Previous experiments from our laboratory have identified selective mRNA and protein expression of a nonselective cation channel known as the canonical transient receptor potential channel 4 (TRPC4s) in brain regions implicated in emotional regulation and anxiety. TRPC4 is highly expressed in the corticolimbic regions of the mammalian brain. We hypothesized that robust corticolimbic expression of TRPC4 may regulate the brain’s... Tipo: Manuscript Palavras-chave: Genetics & Genomics; Neuroscience. Ano: 2011 URL: http://precedings.nature.com/documents/6367/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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