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Effects of granule particle size and lubricant concentration on tablet hardness containing large concentration of polymers BJPS
Rajani,Chauhan; Kumar,Dewangan Devendra; Jaya,Dwivedi; Kumar,Jha Arvind.
ABSTRACT The objective of this research work is to demonstrate the impact of granule size and lubricant concentration on the hardness of tablets in formulations containing higher concentration of polymers and to resolve the hardness issue during compression process. The work involves optimization of a milling process for size reduction of granules and blending process to achieve tablets of good hardness on compression. To optimize the granule size, different sized co-mill screens were used. The different concentration of lubricant were studied on different sized granules to check the effect on hardness of tablets and to obtained the desired hardness of tablets. Compression of lubricated blend in various concentration was performed using the gravity feeder...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Tablet hardness/effects; Granule size; Lubricant concentration; Polymer.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300617
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