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| Chao Liu; Jing Guan; Ying Chen; Kunshen Liu. |
| Glucocorticoids, produced in adrenal cortex, exert potent natriuretic and diuretic actions in the kidney. Recently, it has been found that glucocorticoids could upregulate the expression of natriuretic peptide receptor A (NPR-A), the primary receptor of atrial natriuretic peptide, in the hypothalamus of the rat. Consequently, systemic administration of glucocorticoid could block dehydration-induced water intake by activation hypothalamic NPR-A. We describe here glucocorticoids could inhibit sodium intake when administrated systemically in conscious, salt-depleted rats; an effect which was strong and long-lasting. The study provided further evidence for the actions of glucocorticoids on central nervous system, which together with their established renal... |
| Tipo: Manuscript |
Palavras-chave: Neuroscience; Pharmacology. |
| Ano: 2010 |
URL: http://precedings.nature.com/documents/5376/version/1 |
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| Chao Liu; Kunshen Liu. |
| Background: The role of glucocorticoids in body fluid control is full of controversy. It is well documented that glucocorticoids could produce potent and persistent diuresis in congestive heart failure. But, the diuretic effect was not reported in patients with euvolemia. 
Objective: To test the hypothesis that the diuresis induced by glucocorticoids is systemic volume dependent. 
Methods: The diuretic effect of glucocorticoids in rats with various systemic volume statuses (i.e. systemic volume depletion, euvolemia, and systemic volume overload, respectively) was recorded. 
Results: Glucocorticoids only produced potent and persistent diuresis in the rats with systemic volume... |
| Tipo: Manuscript |
Palavras-chave: Pharmacology. |
| Ano: 2011 |
URL: http://precedings.nature.com/documents/5559/version/1 |
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