|
|
| Santos,S.R.; Papini,O.; Omosako,C.E.; Pereira,M.D.; Quintavalle,T.B.G.; Riccio,M.F.; Kurata,A.; Pereira,V.A.; Di-Pietro,G.; Della-Paschoa,O.E.; Danhof,M.; Da-Luz,P.L.. |
| R,S-sotalol, a ß-blocker drug with class III antiarrhythmic properties, is prescribed to patients with ventricular, atrial and supraventricular arrhythmias. A simple and sensitive method based on HPLC-fluorescence is described for the quantification of R,S-sotalol racemate in 500 µl of plasma. R,S-sotalol and its internal standard (atenolol) were eluted after 5.9 and 8.5 min, respectively, from a 4-micron C18 reverse-phase column using a mobile phase consisting of 80 mM KH2PO4, pH 4.6, and acetonitrile (95:5, v/v) at a flow rate of 0.5 ml/min with detection at <FONT FACE="Symbol">l</font>ex = 235 nm and <FONT FACE="Symbol">l</font>em = 310 nm, respectively. This method, validated on the basis of R,S-sotalol measurements in spiked... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: R; S-sotalol racemate HPLC analysis fluorescence detection pharmacokinetics cardiac arrhythmias high-risk patients. |
| Ano: 2000 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200006 |
| |
