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	Provedor de dados BJMBR (3) Autor Castillo-Henkel,E.F. (3) Lozano-Cuenca,J. (3) López-Canales,J.S. (3) López-Canales,O.A. (3) López-Mayorga,R.M. (3) Aguilar-Carrasco,J.C. (2) Valencia-Hernández,I. (2) Castillo-Henkel,C. (1) Flores-Herrera,H. (1) Muãoz-Islas,E. (1) Villagrana-Zesati,J.R. (1) Mais... Palavra-chave Rat aorta (3) Vasorelaxation (2) Amfepramone (1) Cardiovascular pharmacology (1) K+ channel (1) K+ channels (1) Metabolic syndrome (1) NO (1) NO-cGMP/PKG pathway (1) Nitric oxide (1) Obesity (1) Potassium channels (1) Rosuvastatin (1) Triiodothyronine (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2020 (1) 2016 (1) 2015 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Pharmacological study of the mechanisms involved in the vasodilator effect produced by the acute application of triiodothyronine to rat aortic rings BJMBR Lozano-Cuenca,J.; López-Canales,O.A.; Aguilar-Carrasco,J.C.; Villagrana-Zesati,J.R.; López-Mayorga,R.M.; Castillo-Henkel,E.F.; López-Canales,J.S.. A relationship between thyroid hormones and the cardiovascular system has been well established in the literature. The present in vitro study aimed to investigate the mechanisms involved in the vasodilator effect produced by the acute application of 10-8–10-4 M triiodothyronine (T3) to isolated rat aortic rings. Thoracic aortic rings from 80 adult male Wistar rats were isolated and mounted in tissue chambers filled with Krebs-Henseleit bicarbonate buffer in order to analyze the influence of endothelial tissue, inhibitors and blockers on the vascular effect produced by T3. T3 induced a vasorelaxant response in phenylephrine-precontracted rat aortic rings at higher concentrations (10-4.5–10-4.0 M). This outcome was unaffected by 3.1×10-7 M glibenclamide,... Tipo: Info:eu-repo/semantics/article Palavras-chave: Triiodothyronine; Rat aorta; Vasorelaxation; NO-cGMP/PKG pathway; K+ channels. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000800604 Possible mechanisms involved in the effect of the subchronic administration of rosuvastatin on endothelial function in rats with metabolic syndrome BJMBR Lozano-Cuenca,J.; Valencia-Hernández,I.; López-Canales,O.A.; Flores-Herrera,H.; López-Mayorga,R.M.; Castillo-Henkel,E.F.; López-Canales,J.S.. Metabolic syndrome is a multifaceted condition associated with a greater risk of various disorders (e.g., diabetes and heart disease). In a rat model of metabolic syndrome, an acute in vitro application of rosuvastatin causes relaxation of aortic rings. Since the outcome of a subchronic rosuvastatin treatment is unknown, the present study explored its effect on acetylcholine-induced vasorelaxation of aortic rings from rats with metabolic syndrome. Animals were submitted to a 16-week treatment, including a standard diet, a cafeteria-style diet (CAF-diet), or a CAF-diet with daily rosuvastatin treatment (10 mg/kg). After confirming the development of metabolic syndrome in rats, aortic segments were extracted from these animals (those treated with... Tipo: Info:eu-repo/semantics/article Palavras-chave: Rosuvastatin; Metabolic syndrome; Rat aorta; Vasorelaxation; NO; K+ channel. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000200607 Mechanisms involved in the vasorelaxant effects produced by the acute application of amfepramone in vitro to rat aortic rings BJMBR López-Canales,J.S.; Lozano-Cuenca,J.; Muãoz-Islas,E.; Aguilar-Carrasco,J.C.; López-Canales,O.A.; López-Mayorga,R.M.; Castillo-Henkel,E.F.; Valencia-Hernández,I.; Castillo-Henkel,C.. Amfepramone (diethylpropion) is an appetite-suppressant drug used for the treatment of overweight and obesity. It has been suggested that the systemic and central activity of amfepramone produces cardiovascular effects such as transient ischemic attacks and primary pulmonary hypertension. However, it is not known whether amfepramone produces immediate vascular effects when applied in vitro to rat aortic rings and, if so, what mechanisms may be involved. We analyzed the effect of amfepramone on phenylephrine-precontracted rat aortic rings with or without endothelium and the influence of inhibitors or blockers on this effect. Amfepramone produced a concentration-dependent vasorelaxation in phenylephrine-precontracted rat aortic rings that was not affected by... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardiovascular pharmacology; Amfepramone; Obesity; Rat aorta; Nitric oxide; Potassium channels. Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000600537 Registros recuperados: 3 Primeira ... 1 ... Última

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