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| SILVA,EDUARDO R. DA; BIZZO,HUMBERTO R.; FERNANDES,PATRÍCIA D.; VEIGA JUNIOR,VALDIR F. DA; LEITÃO,SUZANA G.; OLIVEIRA,DANILO R. DE. |
| ABSTRACT The bioavailability, toxicity, and therapeutic efficacy of a drug is directly related to its administration route. The pulmonary route can be accessed by inhalation after fumigation, vaporization or nebulization. Thus, pharmacological and toxicological evaluation accessed by an apparatus specifically designed and validated for this type of administration is extremely important. Based on pre-existing models, an inhalation chamber was developed. This presents a central structure with five animal holders. The nebulized air passes directly and continuously through these holders and subsequently to an outlet. Evaluation of its operation was performed using clove essential oil, a nebulizer, and a flow meter. The air within the chamber was collected by... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Biological activities; Gas chromatograph; Headspace; Inhalation chamber; Syzygium aromaticum. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401643 |
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