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| BARBOSA,HUMBERTO M.; NASCIMENTO,JAILSON N. DO; ARAÚJO,THIAGO A.S.; DUARTE,FILIPE S.; ALBUQUERQUE,ULYSSES P.; VIEIRA,JEYMESSON R.C.; SANTANA,EDSON R.B. DE; YARA,RICARDO; LIMA,CLÁUDIA S.A.; GOMES,DAYANE A.; LIRA,EDUARDO C.. |
| ABSTRACT Spondias tuberosa Arruda, popularly named as umbu, is native from savanna-like vegetation and widely used for medicinal purposes, however, the toxicological profile is not available yet. This study evaluated the phytochemical profile and acute toxicity and citoxicity of Ethanolic Extract of Spondias tuberosa Arruda Bark (EEStb) in hematological, biochemical and histopathological parameters. Female Wistar rats were divided into: control (C) and animal treated single doses of 300mg/Kg (EEStb300) or 2.000mg/kg body weight (ESStb2.000) of the EEStb. After 24 hours and 14 days from gavage, the behavior, hematological, biochemical and histopathological parameters were assayed. Cytotoxicity effect was evaluated on HEp-2 cell lines. Neither EEStb300 nor... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acute toxicity; Cytotoxicity; Phytomedicine; Safety; Spondias tuberosa Arruda; Toxicology. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501993 |
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| BARROS,BÁRBARA R.S.; BARBOZA,BRUNO RAFAEL; RAMOS,BÁRBARA A.; MOURA,MAIARA C. DE; COELHO,LUANA C.B.B.; NAPOLEÃO,THIAGO HENRIQUE; CORREIA,MARIA TEREZA S.; PAIVA,PATRÍCIA MARIA G.; CRUZ FILHO,IRANILDO JOSÉ DA; SILVA,TÚLIO DIEGO DA; LIMA,CLÁUDIA S.A.; MELO,CRISTIANE M.L. DE. |
| Abstract: Currently, the research of new natural compounds with biological potential demonstrates great ethnopharmacological importance. In this study, we evaluated the biological properties promoted by saline extract from Malpighia emarginata DC leaves, whose objective is to evaluate the antioxidant, antimicrobial and cytotoxicity potential. Phytochemical characterization was performed by UPLC-MS chromatography to identify the chemical compounds. For the antioxidant potential, DPPH, ATT and FRAP methods were used. The antibacterial and antifungal tests were performed evaluating the MIC50, MIC90, CMB and CMF parameters. Moreover, antibiofilm action was evaluated. Cytotoxicity and proliferation were performed using splenocytes from Balb/c mice and were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bioactive compounds; Cytotoxicity; Malpighia emarginata DC; Phytochemical. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100627 |
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| RODRIGUES NETO,AGEU A.; GOMES JÚNIOR,PLÍNIO P.; SILVA,MAURICIO C.; LIMA,CLÁUDIA S.A.; YARA,RICARDO; GUIMARÃES,EMÍLIA B.; SANTANA,EDUARDA S. DE; SILVA,LUZIA A. DA; LIRA,EDUARDO J.R.V. DE; VIEIRA,JEYMESSON R.C.. |
| ABSTRACT Rhizophora mangle is an abundant plant in mangroves and tannic acid is a polyphenol produced by the secondary metabolism of plants. The aim of the study was to evaluate the embryotoxic and embriostatic effects of the aqueous extract of R. mangle and synthetic tannic acid on eggs and larvae of Aedes aegypti. A. aegypti eggs were exposed in duplicate at concentrations of 250, 500, 750 and 1000 µg/mL of extract and tannic acid for a period of 14 days. Mineral water was used as a negative control. The eggs were observed and counted in a stereomicroscope (1.2x). In all extract concentrations there was stimulation in hatching in relation to the control, but only in concentration of 750 mg/mL it was statistically significant. In tannic acid (250µg/ml)... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aedes aegypti; Embryostatic; Embryotoxic; Rhizophora mangle; Tannic acid. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000502141 |
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