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| ARAÚJO,Éverton José Ferreira de; LIMA,Layana Karine Farias; SILVA,Oskar Almeida; JÚNIOR,Luís Mário REZENDE; GUTIERREZ,Stanley Juan Chavez; CARVALHO,Fernando Aécio de Amorim; LIMA,Francisco das Chagas Alves; PESSOA,Cláudia; FREITAS,Rivelilson Mendes de; FERREIRA,Paulo Michel Pinheiro. |
| ABSTRACT Aniba riparia (Lauraceae) is an important medicinal plant found in the Amazon region and presents alkaloids of the type alkamide known as riparins. Riparin A is structurally represented as the fundamental core of all Amazon riparins. This work aimed to assess the in vitro antioxidant, antitumor and antileishmanial effects of riparin A. Riparin A presented weak antioxidant capacity by tecniques of DPPH• (EC50 of 296.2 μg mL-1) and ABTS•+ (EC50 of 450.1 μg mL-1), showed moderate activity against colon carcinoma (HCT-116: IC50 of 21.7 μg mL-1) and leishmanicidal activity on promastigotes of L. amazonensis (IC50 of 307.0 ± 79.6, 193.7 ± 44.3 and 81.8 ± 11.2 μg mL-1, respectively, after 24, 48 and 72 h of incubation). Then, in addition to its... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Bioprospecting; Chemoprevention; Cytotoxicity; Antiparasitic drug. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672016000300309 |
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