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	Provedor de dados 42 (2) Autor LOPES,ANÍBAL GIL (2) CARUSO-NEVES,CELSO (1) FALKENSTEIN,DORIS (1) MORALES,MARCELO M. (1) Palavra-chave (Na+ + K+)ATPase (1) 5-hydroxitryptamine (1) Adenosine (1) CFTR (1) Chloride channel (1) Fluid secretion (1) Kidney (1) Malpighian tubule (1) Na+ -ATPase (1) Nephron (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2000 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última The Cystic Fibrosis Transmembrane Regulator (CFTR) in the kidney 42 MORALES,MARCELO M.; FALKENSTEIN,DORIS; LOPES,ANÍBAL GIL. The cystic fibrosis transmembrane regulator (CFTR) is a Cl- channel. Mutations of this transporter lead to a defect of chloride secretion by epithelial cells causing the Cystic Fibrosis disease (CF). In spite of the high expression of CFTR in the kidney, patients with CF do not show major renal dysfunction, but it is known that both the urinary excretion of drugs and the renal capacity to concentrate and dilute urine is deficient. CFTR mRNA is expressed in all nephron segments and its protein is involved with chloride secretion in the distal tubule, and the principal cells of the cortical (CCD) and medullary (IMCD) collecting ducts. Several studies have demonstrated that CFTR does not only transport Cl- but also secretes ATP and, thus, controls other... Tipo: Info:eu-repo/semantics/article Palavras-chave: CFTR; Kidney; Nephron; Chloride channel. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000300013 Sodium pumps in the Malpighian tubule of Rhodnius sp. 42 CARUSO-NEVES,CELSO; LOPES,ANÍBAL GIL. Malpighian tubule of Rhodnius sp. express two sodium pumps: the classical ouabain-sensitive (Na+ + K+)ATPase and an ouabain-insensitive, furosemide-sensitive Na+-ATPase. In insects, 5-hydroxitryptamine is a diuretic hormone released during meals. It inhibits the (Na+ + K+)ATPase and Na+ -ATPase activities indicating that these enzymes are involved in fluid secretion. Furthermore, in Rhodnius neglectus, proximal cells of Malpighian tubule exposed to hyperosmotic medium, regulate their volume through a mechanism called regulatory volume increase. This regulatory response involves inhibition of the (Na+ + K+)ATPase activity that could lead to accumulation of active osmotic solute inside the cell, influx of water and return to the normal cell volume.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Malpighian tubule; (Na+ + K+)ATPase; Na+ -ATPase; Fluid secretion; Adenosine; 5-hydroxitryptamine. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652000000300014 Registros recuperados: 2 Primeira ... 1 ... Última

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