|
|
| BERNAL,CAROLINA; VARGAS,MACARENA; OSSANDÓN,FRANCISCO; SANTIBÁÑEZ,EUDOCIA; URRUTIA,JULIO; LUENGO,VÍCTOR; ZAVALA,LUIS F; BACKHOUSE,CLAUDIA; PALMA,MARIANA; ARGANDOÑA,JORGE; AGUAYO,FRANCISCO; CORVALÁN,ALEJANDRO. |
| Diffuse type gastric carcinoma is the most aggressive type of gastric cáncer. This type of tumor is not preceded by precancerous changes and is associated with early-onset and hereditary syndromes. To test the hypothesis that DNA methylation profile would be useful for molecular classification of the diffuse type gastric carcinoma, DNA methylation patterns of the CpG Island of 17 genes were studied in 104 cases and 47 normal adjacent gastric mucosa by Methylation-specific PCR, Immunohistochemistry and Hierarchical clustering analysis. The most frequent methylated genes were FHIT, E-cadherin, BRCA1 and APC (>50%), followed by pl4, pl6, pl5, p73, MGMT and SEMA3B (20-49%). Hierarchical clustering analysis reveáis four groups with different clinical... |
| Tipo: Journal article |
Palavras-chave: Gastric cáncer; Diffuse type; Early-onset; BRCA-1. |
| Ano: 2008 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000300007 |
| |
