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Registros recuperados: 4
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STRING and STITCH: known and predicted interactions between proteins and chemicals 17
Lars J. Jensen; Michael Kuhn; Manuel Stark; Samuel Chaffron; Christian von Mering; Peer Bork.
Information on protein-protein and protein-chemical interactions is essential for understanding cellular functions. The STRING and STITCH web resources integrate interaction evidence derived from pathways, automatic literature mining, primary experimental data, and genomic context. The resulting interaction networks cover 1.5 million proteins from 373 organisms and 68,000 chemicals.
Tipo: Poster Palavras-chave: Bioinformatics.
Ano: 2008 URL: http://precedings.nature.com/documents/2265/version/1
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Reflect: Augmented Browsing for the Life Scientist 17
Evangelos Pafilis; Seán I. O'Donoghue; Lars J. Jensen; Heiko Horn; Michael Kuhn; Nigel P. Brown; Reinhard Schneider.
Anyone who regularly reads life science literature often comes across names of genes, proteins, or small molecules that they would like to know more about. To make this process easier, we have developed a new, free service called Reflect ("http://reflect.ws":http://reflect.ws) that can be installed as a plug-in to Firefox or Internet Explorer. Reflect tags gene, protein, and small molecule names in any web page, typically within a few seconds, and without affecting document layout. Clicking on a tagged gene or protein name opens a popup showing a concise summary that includes synonyms, database identifiers, sequence, domains, 3D structure, interaction partners, subcellular location, and related literature. Clicking on a tagged small...
Tipo: Manuscript Palavras-chave: Biotechnology; Chemistry; Genetics & Genomics; Molecular Cell Biology; Bioinformatics.
Ano: 2009 URL: http://precedings.nature.com/documents/3212/version/1
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The What, Why and How of openness in science 17
Konrad U. Foerstner; Lars J. Jensen.
We give a short introduction to open science followed by an overview of Creative Commons and open source licenses.
Tipo: Presentation Palavras-chave: Bioinformatics.
Ano: 2008 URL: http://precedings.nature.com/documents/1655/version/1
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Just-in-time assembly of cell-cycle protein complexes 17
Lars J. Jensen; Ulrik de Lichtenberg; Thomas S. Jensen; Søren Brunak; Peer Bork.
Our comparative analysis of eukaryotic cell-cycle complexes reveals that the identity of the periodically expressed subunits differs significantly between organisms and is often mirrored by changes in cell-cycle-dependent phosphorylation of the protein products. This indicates that many different solutions have evolved for just-in-time assembly of the same molecular machines.
Tipo: Poster Palavras-chave: Molecular Cell Biology; Bioinformatics.
Ano: 2008 URL: http://precedings.nature.com/documents/2273/version/1
Registros recuperados: 4
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