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	Provedor de dados BJMBR (3) Autor Leão,R.M. (3) Beirão,P.S.L. (1) Carneiro-de-Oliveira,P.E. (1) Cruz,F.C. (1) Cruz,J.S. (1) Mafra,R.A. (1) Marin,M.T. (1) Planeta,C.S. (1) Zago,A. (1) von Gersdorff,H. (1) Mais... Palavra-chave Adolescence (1) Calcium buffer (1) Calyx of Held (1) Capacitance measurements (1) Cerebellar granule neurons (1) Cross-sensitization (1) Excitatory amino-acid transporter type 2 (1) Glutamate (1) Locomotor activity (1) Mammalian auditory brainstem (1) Neurotransmission (1) Nicotine (1) Patch-clamp (1) Stress (1) Synaptic development (1) Whole-cell voltage-clamp (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2012 (1) 2009 (1) 2003 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Synaptic vesicle pool size, release probability and synaptic depression are sensitive to Ca2+ buffering capacity in the developing rat calyx of Held BJMBR Leão,R.M.; von Gersdorff,H.. The calyx of Held, a specialized synaptic terminal in the medial nucleus of the trapezoid body, undergoes a series of changes during postnatal development that prepares this synapse for reliable high frequency firing. These changes reduce short-term synaptic depression during tetanic stimulation and thereby prevent action potential failures during a stimulus train. We measured presynaptic membrane capacitance changes in calyces from young postnatal day 5-7 (p5-7) or older (p10-12) rat pups to examine the effect of calcium buffer capacity on vesicle pool size and the efficiency of exocytosis. Vesicle pool size was sensitive to the choice and concentration of exogenous Ca2+ buffer, and this sensitivity was much stronger in younger animals. Pool size and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Calyx of Held; Neurotransmission; Calcium buffer; Capacitance measurements; Mammalian auditory brainstem; Synaptic development. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000100014 Effects of simultaneous exposure to stress and nicotine on nicotine-induced locomotor activation in adolescent and adult rats BJMBR Zago,A.; Leão,R.M.; Carneiro-de-Oliveira,P.E.; Marin,M.T.; Cruz,F.C.; Planeta,C.S.. Preclinical studies have shown that repeated stress experiences can result in an increase in the locomotor response to the subsequent administration of drugs of abuse, a phenomenon that has been termed behavioral cross-sensitization. Behavioral sensitization reflects neuroadaptive processes associated with drug addiction and drug-induced psychosis. Although cross-sensitization between stress- and drug-induced locomotor activity has been clearly demonstrated in adult rats, few studies have evaluated this phenomenon in adolescent rats. In the present study, we determined if the simultaneous exposure to stress and nicotine was capable of inducing behavioral sensitization to nicotine in adolescent and adult rats. To this end, adolescent (postnatal day (P)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cross-sensitization; Locomotor activity; Nicotine; Stress; Adolescence. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000100006 Electrophysiological evidence for glial-subtype glutamate transporter functional expression in rat cerebellar granule neurons BJMBR Mafra,R.A.; Leão,R.M.; Beirão,P.S.L.; Cruz,J.S.. A glutamate-sensitive inward current (Iglu) is described in rat cerebellar granule neurons and related to a glutamate transport mechanism. We examined the features of Iglu using the patch-clamp technique. In steady-state conditions the Iglu measured 8.14 ± 1.9 pA. Iglu was identified as a voltage-dependent inward current showing a strong rectification at positive potentials. L-Glutamate activated the inward current in a dose-dependent manner, with a half-maximal effect at about 18 µM and a maximum increase of 51.2 ± 4.4%. The inward current was blocked by the presence of dihydrokainate (0.5 mM), shown by others to readily block the GLT1 isoform. We thus speculate that Iglu could be attributed to the presence of a native glutamate transporter in cerebellar... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cerebellar granule neurons; Excitatory amino-acid transporter type 2; Patch-clamp; Glutamate; Whole-cell voltage-clamp. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000700018 Registros recuperados: 3 Primeira ... 1 ... Última

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