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| Araújo,Danielle Dayse; Leal,Marineide Marinho; Santos,Eliane Jucielly Vasconcelos; Leal,Leila Bastos. |
| The use of drugs during pregnancy still represents a challenge for medicine, since the majority of drugs cross the placental barrier with a potential to cause several congenital problems to the fetus, and most of them have not been clinically tested in pregnant patients. At the same time, the medicalization phenomenon, self-medication, and lack of patient information about the misuse of medicines are additional problems. Thus, the aim of this study was to evaluate the pattern of medicine consumption in high-risk pregnancies and the determinants related to this consumption pattern. In order to do so, a cross-sectional descriptive study was performed with puerperal women who had a history of high-risk pregnancy. Statistically significant associations were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Medicines/adverse effects; Pregnancy/medicines use; Self-medication; Health education. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000300010 |
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| Cavalcanti,Noely Camila Tavares; Sousa,Giovana Damasceno; Tabosa,Maria Alice Maciel; Soares Sobrinho,José Lamartine; Leal,Leila Bastos; Santana,Davi Pereira de. |
| The aim of this study was to characterize three batches of albendazole by pharmacopeial and complementary analytical techniques in order to establish more detailed specifications for the development of pharmaceutical forms. The ABZ01, ABZ02, and ABZ03 batches had melting points of 208 ºC, 208 ºC, and 209 ºC, respectively. X-ray diffraction revealed that all three batches showed crystalline behavior and the absence of polymorphism. Scanning electron microscopy showed that all the samples were crystals of different sizes with a strong tendency to aggregate. The samples were insoluble in water (5.07, 4.27, and 4.52 mg mL-1, respectively) and very slightly soluble in 0.1 M HCl (55.10, 56.90, and 61.70 mg mL-1, respectively) and additionally showed purities... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Albendazole/characterization; Antiparasitics/quality control. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000200012 |
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| Melo,Elayne Karine Souto de; Araujo,Thalita Pedon de; Silva,José Wellithom Viturino da; Chagas,Stephanye Carolyne Christino; Bedor,Danilo César Galindo; Santana,Davi Pereira de; Leal,Leila Bastos. |
| ABSTRACT Metronidazole (MTZ) is widely used as the standard antibiotic for the treatment of rosacea and, more recently, is being used off label in Brazilian hospitals for the treatment of wounds. Following oral administration, minimal amounts of active agent reaches the skin and side effects are strongly induced. Consequently, MTZ is currently being applied topically in order to improve the therapeutic efficacy with reduced side effects, with Rozex(r) (RZ) (an MTZ gelled formulation) being the only marketed product. This study examined whether the use of MTZ 0.75% from thermogel formulations could improve drug retention and reduce dermal exposure compared to that by Rozex(r). Following a 21 h permeation study, the highest total amount of MTZ permeated... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Metronidazole/evaluation; Metronidazole/drug retention; Poloxamer 407; Rosacea/treatment; Dermatopharmacokinetic.. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200626 |
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| Leal,Leila Bastos; Sousa,Giovana Damasceno; Seixas,Karoline Belém; Souza,Pedro Henrique Nogueira de; Santana,Davi Pereira de. |
| The aims of this study were to determine the critical hydrophile-lipophile balance (HLB) of licuri oil, and to perform a clinical assay to evaluate its hydrating effects. For the determination of the HLB, serial emulsions were prepared with the oil. Regarding the clinical study, 13 human subjects were recruited to evaluate the hydrating power of the emulsified preparation containing licuri oil, and comparing it with the same preparation containing sweet almond oil (SAO). The critical HLB of licuri oil was represented by the zones within the concentrations of 10% for the oil and 15% for the pair of tensoactive agents, with a value of 11.8. Both preparations showed similar hydrating power. We propose that licuri oil can be considered a new lipophilic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Licuri/fixed oil; Licuri/determination of hydrophile-lipophile balance; Licuri/fixed oil; Licuri/hydration effects; Emulsions/preparation with licuri oil; Skin hydration. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100018 |
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