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| Lee,K. H.; Won,H. J.; Kim,S. N.; Yoo,S. H.; Shin,I. S.; Shin,K. H.; Hong,S. H.; Lee,S. H.; Min,H. K.; Park,S. N.; Hur,S. J.. |
| In Korea, antivenoms for the treatment of patients bitten by venomous snakes have been imported from Japan or China. Although there is cross-reactivity between these antibodies and venoms from snakes indigenous to Korea (e.g. Agkistrodon genus), protection is not optimal. Antivenoms specifically prepared to neutralize Korean snake venoms could be more effective, with fewer side effects. To this end, we established an infrastructure to develop national standards and created a standardized method to evaluate the efficacy of two horse-derived antivenoms using mouse lethal toxin test. Additionally, we determined the antivenoms neutralizing activity against lethal doses (LD50) of Agkistrodon halys (from Japan) and Jiangzhe Agkistrodon halys (from China) venoms.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Anti-lethal toxin potency; Jiangzhe Angkistrodon halys; Lethal activity; Probit analysis; Slope. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000400004 |
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| Lee,K. H.; Hur,S. J.; Kim,S. N.; Yoo,S. H.; Shin,I. S.; Won,H. J.; Shin,K. H.; Hong,S. H.; Lee,S. H.; Min,H. K.; Park,S. N.. |
| To establish Korea National Standards for venoms and antivenoms, it is necessary to have standardized assay methods. In this study, we standardized a method to evaluate the antihemorrhagic potency of two horse-derived antivenoms using rabbit intracutaneous injection. We expressed the capability of these antivenoms to neutralize the hemorrhagic activities triggered by the venoms of Agkistrodon halys from Japan and Jiangzhe Agkistrodon halys from China as Minimum Hemorrhagic Dose (MHD). We also performed cross-neutralization tests employing the parallel line assay on different pairings of venoms and antivenoms to check the possibility of using Jiangzhe Agkistrodon halys venom as a substitute for the standard Agkistrodon halys venom in measurements of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antihemorrhagic potency; Minimum hemorrhagic dose; Jiangzhe Agkistrodon halys; Parallel line assay. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000300009 |
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