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| Leman-loubiere, Charlotte; Le Goff, Geraldine; Debitus, Cecile; Ouazzani, Jamal. |
| Four new sporochartines B-E were isolated from the marine fungus Hypoxylon monticulosurn CLL-205, isolated from a sponge belonging to the Sphaerocladina order and collected in Tahiti coast. Sporochartine A (1), the first representative of this family was previously isolated from the same fungus. The structures of sporochartines B-E were elucidated using 1D and 2D NMR, HRMS and IR data. Their configurations were established according to ROE correlations and comparison with the absolute configuration of sporochartine A (1) previously obtained from X-ray analysis. Sporochartines A-D (2-4) may be derived from endo Diels-Alderase type catalysis and sporochartine E (5) from an exo Diels-Alderase catalysis. The spatial conformation of sporochartines drastically... |
| Tipo: Text |
Palavras-chave: Hypoxylon; Sphaerocladina; Sporothriolide; Sporochartines; Cytotoxic compounds. |
| Ano: 2017 |
URL: https://archimer.ifremer.fr/doc/00602/71415/69899.pdf |
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