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| Arrym,Mauro Pedromonico; Alves,Paulo César Martins; Castelhano,Mariana Virginello; Mazzola,Taís Nitsch; Lemos,Renata Muller Banzato Pinto de; Zaccariotto,Tânia Regina; Levy,Carlos Emilio; Guimarães,Fernando; Silva,Marcos Tadeu Nolasco da. |
| ABSTRACT Background: HIV infection harms adaptive cellular immunity mechanisms. Long-term virological control by combined antiretroviral therapy (cART) reduces the risk of mycobacterial infections. Thus, we aimed to study cellular responses to mycobacterial antigens in 20 HIV-infected adolescents with at least one year of virological control (HIV-RNA <40 copies/mL) and 20 healthy adolescents. Methods: We evaluated CD8 and γδ T-cell degranulation by measurement of CD107a membrane expression after stimulation with lysates from BCG (10 µg/mL) and H37RA Mycobacterium tuberculosis (Mtb, 10 µg/mL). Immune activation and antigen-presenting ability were also assessed by determination of HLA-DR, CD80, and CD86 markers. Results: TCR γδ T-cell CD107a expression... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV/Aids; BCG; Youth; Tuberculosis; Citotoxicity; Immunologic. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300151 |
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| Ernesto,Aline Santarem; Lemos,Renata Muller Banzato Pinto de; Huehara,Maria Ivone; Morcillo,André Moreno; Vilela,Maria Marluce dos Santos; Silva,Marcos Tadeu Nolasco da. |
| INTRODUCTION: Adherence, which is crucial to the success of antiretroviral therapy (HAART), is currently a major challenge in the care of children and adolescents living with HIV/AIDS. OBJECTIVE: To evaluate the prevalence of nonadherence to HAART using complementary instruments in a cohort of children and adolescents with HIV/AIDS followed in a reference service in Campinas, Brazil. METHODS: The level of adherence of 108 patients and caregivers was evaluated by an adapted standardized questionnaire and pharmacy dispensing records (PDR). Non-adherence was defined as a drug intake lower than 95% (on 24-hour or seven-day questionnaires), or as an interval of 38 days or more for pharmacy refills. The association between adherence and clinical, immunological,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Acquired immunodeficiency; Syndrome; Child; Adolescent; Highly active antiretroviral therapy; Medication adherence. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400001 |
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