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| Botelho,M.A.; Nogueira,N.A.P.; Bastos,G.M.; Fonseca,S.G.C.; Lemos,T.L.G.; Matos,F.J.A.; Montenegro,D.; Heukelbach,J.; Rao,V.S.; Brito,G.A.C.. |
| Dental caries and periodontal disease are associated with oral pathogens. Several plant derivatives have been evaluated with respect to their antimicrobial effects against such pathogenic microorganisms. Lippia sidoides Cham (Verbenaceae), popularly known as "Alecrim-pimenta" is a typical shrub commonly found in the Northeast of Brazil. Many plant species belonging to the genus Lippia yield very fragrant essential oils of potential economic value which are used by the industry for the commercial production of perfumes, creams, lotions, and deodorants. Since the leaves of L. sidoides are also extensively used in popular medicine for the treatment of skin wounds and cuts, the objective of the present study was to evaluate the composition and antimicrobial... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Lippia sidoides; Essential oil; Antimicrobial activity; Oral pathogens. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300010 |
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| Costa-Lotufo,L.V.; Ferreira,M.A.D.; Lemos,T.L.G.; Pessoa,O.D.L.; Viana,G.S.B.; Cunha,G.M.A.. |
| Auxemma oncocalyx Taub. belongs to the Boraginaceae family and is native to the Brazilian northeast where it is known as "pau-branco". We investigated the ability of the water soluble fraction isolated from the heartwood of A. oncocalyx to inhibit sea urchin egg development. This fraction contains about 80% oncocalyxone A (quinone fraction), a compound known to possess strong cytotoxic and antitumor activities. In fact, the quinone fraction inhibited cleavage in a dose-dependent manner [IC50 of 18.4 (12.4-27.2) µg/ml, N = 6], and destroyed the embryos in the blastula stage [IC50 of 16.2 (13.7-19.2) µg/ml, N = 6]. We suggest that this activity is due to the presence of oncocalyxone A. In fact, these quinones present in A. oncocalyx extract have strong... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Auxemma oncocalyx; Quinones; Sea urchin eggs; Oncocalyxone A. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000800010 |
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