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| Fu, Z.; Huang, J.; Li, G.; Zhang, G.; Zhou, M.. |
| Rabies virus (RABV) is a neurotropic virus that causes fatal disease in humans and animals. Currently there is no cure for rabies once clinical signs appear. It has been hypothesized that once the virus enters the central nervous system (CNS), neutralizing antibodies in the periphery cannot cross the blood– brain barrier (BBB) into the CNS. Previous studies have demonstrated that treatment with live-attenuated RABV via the intracerebral route 5 days after infection with wild-type viruses can lead to the clearance not only the attenuated, but also the wild-type virus. Direct administration of liveattenuated RABV stimulated high levels of neutralization antibodies and enhanced the BBB permeability. However, direct intracerebral administration of... |
| Tipo: Info:eu-repo/semantics/article |
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| Ano: 2013 |
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/248 |
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