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Poor sleep in middle-aged women is not associated with menopause per se BJMBR
Tao,M.F.; Sun,D.M.; Shao,H.F.; Li,C.B.; Teng,Y.C..
Whether sleep problems of menopausal women are associated with vasomotor symptoms and/or changes in estrogen levels associated with menopause or age-related changes in sleep architecture is unclear. This study aimed to determine if poor sleep in middle-aged women is correlated with menopause. This study recruited women seeking care for the first time at the menopause outpatient department of our hospital. Inclusion criteria were an age ≥40 years, not taking any medications for menopausal symptoms, and no sleeping problems or depression. Patients were assessed with the Pittsburgh Sleep Quality Index (PSQI), modified Kupperman Index (KI), and Menopause Rating Scale (MRS). A PSQI score of <7 indicated no sleep disorder and ≥7 indicated a sleep disorder....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Kupperman Index; Menopause; Menopause Rating Scale; Pittsburgh Sleep Quality Index; Sleep disorder; Quality of life.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000100701
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Ghrelin attenuates the growth of HO-8910 ovarian cancer cells through the ERK pathway BJMBR
Bai,R.X.; Wang,W.P.; Zhao,P.W.; Li,C.B..
Ovarian cancer is one of the most common causes of death from gynecologic tumors and is an important public health issue. Ghrelin is a recently discovered bioactive peptide that acts as a natural endogenous ligand of the growth hormone secretagogue receptor (GHSR). Several studies have identified the protective effects of ghrelin on the mammalian reproductive system. However, little research has been done on the effects of ghrelin on ovarian cancer cells, and the underlying mechanisms of these effects. We sought to understand the potential involvement of mitogen-activated protein kinases (MAPKs) in ghrelin-mediated inhibition of growth of the ovarian line HO-8910. We applied different concentrations of ghrelin and an inhibitor of the ghrelin receptor...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ghrelin; MAPKs; HO-8910; Apoptosis.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000300602
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