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	Provedor de dados Genet. Mol. Biol. (1) Autor Cheng,De (1) Gao,Xing (1) Li,Zhenzhen (1) Liu,Yajun (1) Wang,Huayan (1) Palavra-chave DNA microarray analysis (1) Embryonic stem cells (1) Gene expression profiling (1) Induced pluripotent stem cells (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2012 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última The gene expression profiles of induced pluripotent stem cells (iPSCs) generated by a non-integrating method are more similar to embryonic stem cells than those of iPSCs generated by an integrating method Genet. Mol. Biol. Liu,Yajun; Cheng,De; Li,Zhenzhen; Gao,Xing; Wang,Huayan. Induced pluripotent stem cells (iPSCs) obtained by the ectopic expression of defined transcription factors have tremendous promise and therapeutic potential for regenerative medicine. Many studies have highlighted important differences between iPSCs and embryonic stem cells (ESCs). In this work, we used meta-analysis to compare the global transcriptional profiles of human iPSCs from various cellular origins and induced by different methods. The induction strategy affected the quality of iPSCs in terms of transcriptional signatures. The iPSCs generated by non-integrating methods were closer to ESCs in terms of transcriptional distance than iPSCs generated by integrating methods. Several pathways that could be potentially useful for studying the molecular... Tipo: Info:eu-repo/semantics/article Palavras-chave: DNA microarray analysis; Embryonic stem cells; Gene expression profiling; Induced pluripotent stem cells. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000400022 Registros recuperados: 1 Primeira ... 1 ... Última

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