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| Palma-Cano,Luz Elena; Córdova,Emilio J.; Orozco,Lorena; Martínez-Hernández,Angélica; Cid,Miguel; Leal-Berumen,Irene; Licón-Trillo,Angel; Lechuga-Valles,Ruth; González-Ponce,Mauricio; González-Rodríguez,Everardo; Moreno-Brito,Verónica. |
| Abstract The GSTT1 and GSTM1 genes are key molecules in cellular detoxification. Null variants in these genes are associated with increase susceptibility to developing different types of cancers. The aim of this study was to determine the prevalence of GSTT1 and GSTM1 null genotypes in Mestizo and Amerindian individuals from the Northwestern region of Mexico, and to compare them with those reported worldwide. GSTT1 and GSTM1 null variants were genotyped by multiplex PCR in 211 Mestizos and 211 Amerindian individuals. Studies reporting on frequency of GSTT1 and GSTM1 null variants worldwide were identified by a PubMed search and their geographic distribution were analyzed. We found no significant differences in the frequency of the null genotype for GSTT1... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Oxidative stress; GSTT1; GSTM1; Null variants. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000500727 |
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