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	Provedor de dados BJMBR (2) Autor Lima,C.S.P. (2) Arruda,V.R. (1) Costa,F.F. (1) Latuf Filho,P. (1) Moreira,L.R. (1) Saad,S.T.O. (1) Schenka,A.A. (1) Trevisan,M.A.S. (1) Vassallo,J. (1) Mais... Palavra-chave Angiogenesis (1) CD105 (1) Colorectal adenoma (1) Colorectal cancer (1) D2-40 (1) Hemoglobinopathy (1) Hydroxyurea (1) Immunohistochemistry (1) Sickle cell disease (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2009 (1) 1997 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Minimal doses of hydroxyurea for sickle cell disease BJMBR Lima,C.S.P.; Arruda,V.R.; Costa,F.F.; Saad,S.T.O.. The use of hydroxyurea (HU) can improve the clinical course of sickle cell disease. However, several features of HU treatment remain unclear, including the predictability of drug response and determination of adequate doses, considering positive responses and minimal side effects. In order to identify adequate doses of HU for treatment of sickle cell disease, 10 patients, 8 with sickle cell anemia and 2 with Sß thalassemia (8SS, 2Sß), were studied for a period of 6 to 19 months in an open label dose escalation trial (10 to 20 mg kg-1 day-1). Hemoglobin (Hb), fetal hemoglobin (Hb F) and mean corpuscular volume (MCV) values and reticulocyte, neutrophil and platelet counts were performed every two weeks during the increase of the HU dose and every 4 weeks... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sickle cell disease; Hydroxyurea; Hemoglobinopathy. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800004 Comparison of blood neoangiogenesis and lymphatic vascularization in colorectal adenomas from patients with and without concomitant colorectal cancer BJMBR Moreira,L.R.; Schenka,A.A.; Latuf Filho,P.; Lima,C.S.P.; Trevisan,M.A.S.; Vassallo,J.. Blood and lymphatic vessel proliferation is essential for tumor growth and progression. Most colorectal carcinomas develop from adenomas (adenoma-carcinoma sequence) in a process due to accumulation of molecular genetic alterations. About 5% of adenomatous polyps are expected to become malignant, but data on the differential angiogenic patterns of these lesions in patients with and without concomitant cancer are missing. The aim of the present study is to compare the angiogenic and lymphatic patterns of adenomatous polyps from patients with and without sporadic cancer. Thirty adenomatous polyps (15 from patients with another principal malignant lesion, and 15 from patients without cancer) were submitted to immunohistochemical staining for CD105 (marker for... Tipo: Info:eu-repo/semantics/article Palavras-chave: Angiogenesis; Colorectal adenoma; Colorectal cancer; Immunohistochemistry; CD105; D2-40. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000700002 Registros recuperados: 2 Primeira ... 1 ... Última

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