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| Du,C.W.; Wen,B.G.; Li,D.R.; Peng,X.; Hong,C.Q.; Chen,J.Y.; Lin,Z.Z.; Hong,X.; Lin,Y.C.; Xie,L.X.; Wu,M.Y.; Zhang,H.. |
| Nasopharyngeal carcinoma (NPC) is notorious for the metastases, which are in close association with Epstein-Barr virus-encoded latent membrane protein 1 (LMP1). Arsenic trioxide (As2O3) has been shown to induce apoptosis and differentiation in NPC xenografts. Then, can it repress the cancer cells' metastasis potential? To elucidate this issue, the present study was performed. LMP1-negative cell line HNE1 and LMP1-positive cell line HNE1-LMP1 were used as in vitro model. Cells (1 x 10(5)/mL) were cultured with or without 3 µM As2O3 for 48 h. Then the survival cells were collected to investigate their potential of colony formation, attachment, invasion, and migration. Both confocal immunofluorescence staining and Western blot were used to detect the changes... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Arsenic trioxide (As2O3); Nasopharyngeal carcinoma; Metastases; Latent membrane protein 1; Metalloproteinase 9. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000500015 |
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