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Low Protein Diet Consumption Antagonize the Age-associated Change in Hypothalamic GABA Receptor activity 17
Bidhan C. Bandyopadhyay; Lina Chakrabarti; Mrinal K. Poddar.
Amounts of dietary protein as well as the duration of its supplementation are critical
factors that correlate with the hypothalamic GABAergic activity and immune function
during aging. Here we evaluate the effect of low (5%) and high (40%) protein diet on the
functional state of hypothalamic GABA receptor in the aging brain in albino rats. Longterm
(LT; for 30 consecutive days) supplementation of low protein diet (LDP) retarded
the age-associated (3 to 18 months) (a) loss of both low and high affinity hypothalamic
GABA receptor sensitivity and (b) increase of high affinity GABA receptor density.
Short-term (ST; for 7 consecutive days)...
Tipo: Manuscript Palavras-chave: Neuroscience; Pharmacology.
Ano: 2008 URL: http://precedings.nature.com/documents/2284/version/1
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